Stable Isotopes in Pharmaceutical Research by T.R. Browne

By T.R. Browne

Strong isotope ideas supply merits in security, sensitivity, specificity, and economic system for lots of forms of pharmaceutical investigations in comparison to traditional thoughts. however, pharmaceutical researchers are sluggish to include solid isotope techniques.This publication assembles in a single position finished reports of the various functions of reliable isotopes and the heritage fabric essential to comprehend the appliance. This technique is a planned try and motivate using sturdy isotopes in pharmaceutical examine. an advantage to the reader is the excessive average of contributions from a truly gifted and numerous workforce of investigators.

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W. McLafferty, Interpretation of Mass Spectra, 3rd edn (University Science Books, Mill Valley, California, 1980). 19. J. D. A. Neville and A. West, Rapid Commun. , 4 (1990) 88. 20. J. C. L. L. Yergey, Anal. , 55 (1983) 1741. 47 CHAPTER 4 MASS SPECTROMETRY: LIQUID C H R O M A T O G R A P H Y - MASS SPECTROMETRY JAMES E. EVANS E. K. , Waltham, MA 02254 1. 1. Background For nearly thirty years, mass spectrometry (MS) has been the premier technique for the detection, structure determination and quantitation of compounds labeled with stable isotopes.

I,,= " . I . , , 100 MIZ Figure 4. (a) Electron ionization, and (b) chemical ionization spectra of histamine (MW 111) (8). commonly referred to as a soft or mild ionization technique. For CI to occur, the analyte molecule must be in the gas state, at a lower vacuum than for El (about 10 -1 to 10 -2 Torr), and the presence of a reagent gas. g. methane, ammonia or in some cases solvent molecules) is in large excess in the ion source and undergoes El to produce reactant ions that can abstract a proton from the vaporized analyte to generate a quasi-molecular ion ([M + H] § (Eq.

The fast atom beam was focused directly onto the belt where the residues were ionized. Addition of matrix to the belt was difficult and often had little or negative effect on the resulting spectra. Moving belt FAB was difficult to use and did not provide the necessary sensitivity or the soft ionization of probe FAB to make it a method that was useful for practical analyses. Continuous flow FAB (CF/FAB, also termed frit FAB or dynamic FAB) was introduced by Ito et al. (36) as a much simpler and more successful approach to on-line LC-FAB-MS.

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