Pharmaceutical coating technology by Michael Aulton, Graham Cole, John Hogan

By Michael Aulton, Graham Cole, John Hogan

This e-book is the definitive paintings at the conception and perform of pharmaceutical pill and pellet coating. It describes either the sensible and theoretical features of pill coating, together with the apparatus and techniques utilized in laboratory improvement, scale-up and construction structures, in addition to automation and validation. This ebook additionally discusses the issues of conforming to world-wide rules, and the dangers of Read more...

summary: This publication is the definitive paintings at the thought and perform of pharmaceutical capsule and pellet coating. It describes either the sensible and theoretical elements of pill coating, together with the apparatus and techniques utilized in laboratory improvement, scale-up and construction structures, in addition to automation and validation. This e-book additionally discusses the issues of conforming to world-wide laws, and the risks of environmental toxins

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Ethylcellulose also conveys additional gloss and shine to the tablet surface. In many ways ethylcellulose is an ideal polymer for modified release coatings. It is odourless, tasteless and it exhibits a high degree of stability not only under physiological conditions but also under normal storage conditions, being stable to light and heat at least up to its softening point of c. 135°C (Rowe, 1985). Commercially, ethylcellulose is available in a wide range of viscosity and substitution types giving a good range of possibilities for the formulator.

It is odourless, tasteless and it exhibits a high degree of stability not only under physiological conditions but also under normal storage conditions, being stable to light and heat at least up to its softening point of c. 135°C (Rowe, 1985). Commercially, ethylcellulose is available in a wide range of viscosity and substitution types giving a good range of possibilities for the formulator. It also possesses good solubility in common solvents used for film coating but this feature is nowadays of lesser importance with the advent of water-dispersible presentations of ethylcellulose which have been especially designed for modified release coatings.

This has the advantage over, for example, a coating solution prepared from a 50 mPa s grade (E50) where only a 5%w/w solids concentration could be achieved. The lower viscosity grade polymer permits a higher solids concentration to be used, with consequent reduction in solvent content of the solution. The practical advantage to be gained is that the lower the solvent content of the solution, the shorter will be the processing time as less solvent has to be removed Page 21 Fig. 3 Comparison of solution viscosity of three commercially available HPMC grades.

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