By Robert Morfin
DHEA and the mind stories quite a number latest reviews concerning DHEA management to animals and people. bankruptcy authors assessment DHEA metabolism in tissues and organs, discover DHEA results within the liver which may be of value to the mind, and talk about contemporary findings concerning how DHEA is made within the mind. New views in regards to the neuroprotective results of DHEA are awarded, in addition to perception concerning DHEA metabolism within the brain.A variety of well-being merits were linked to dehydroepiandrosterone (DHEA), together with anti-cancer, anti-osteoporosis, anti-atherosclerosis, anti-diabetes, immuno-stimulating, and memory-enhancing results. This has brought on thousands of individuals to take this hormone as an everyday dietary complement. even if, there's a few predicament that lengthy self-administration can result in health difficulties, in addition to unease approximately power unwanted side effects end result of the creation of steroid derivatives within the tissues.Featuring an esteemed panel of individuals, this quantity presents an authoritative review of the examine pertaining to DHEA and the mind. It offers a number of leading edge techniques and concepts for destiny investigations into the physiological activities of this hormone.
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Additional info for DHEA and the Brain (Nutrition, Brain, and Behavior)
1999). , 1997); (iii) physiological fluctuations in circulating levels of neuroactive steroids in fertile women appear to impact on brain cortical function. e. , 1999). Thus, although studies in laboratory animals indicate that local synthesis/metabolism influences brain neurosteroid concentrations, changes in circulating neuroactive steroids may also reasonably reflect changes in brain and higher blood concentrations of precursors may contribute to an enhanced synthesis of neurosteroids in brain.
To lay emphasis on this novel non-genomic mechanism of action, that implies a function for neurosteroids as direct modulators of intercellular signaling in brain, Paul and Purdy (1992) introduced the term “neuroactive steroid”. , 1999), an effect that, according to some (Imamura and Prasad, 1998) but not other authors (Sousa and Ticku, 1997), is exhibited also by DHEA. , allopregnanolone and allotetrahydro-deoxycorticosterone. , 1997) and increase of pentobarbital and ethanol-induced sleeping time (Melchior and Ritzman, 1992), after systemic administration.
The first volume in this series is DHEA and the Brain edited by Professor Robert Morfin of the University of Paris, France. Subsequent issues will focus on antioxidant vitamins, essential fatty acids, amino acids (tyrosine and tryptophan), nutrition and developing brain, and nutrition and the adult brain. I hope this series will become an essential source book for nutritionists, psychiatrists and internists. I would like to take this opportunity to thank Professor Robert Morfin, the editor for the first volume in the series and the members of the Editorial Advisory Board (Drs Galler, Guedes, Huether, Kastin and Lieberman) for their help in getting this project off the ground.