Combinatorial Peptide and Nonpeptide Libraries: A Handbook by Günther Jung

By Günther Jung

Reference on compound libraries of peptides, for researchers in natural synthesis, biochemistry, biotechnology, pharmacology, medication, and scientific chemistry. broad assurance of artificial techniques and applied sciences, mass spectrometry, and screening assays. forty seven participants, 21 U.S.

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481 K. Burgess, D. Scott Linthicum, H. Shin, Angew. Chem. 1995, 107, 975-977; Angew Chem. Int. Ed. Engl. 1995, 34, 907-909. [49] A. B. Smith, T. P. Keenan, R. C. Holcomb, P. A. Sprengeler, M. C. Guzman, J. L. Wood, P. J. Carroll, R. Hirschmann, J Am. Chem. Soc. 1992, 114, 10672-10674. [SO] M. Hagihara, N. J. Anthony, T. J. Stout, J. Clardy, S. L. Schreiber, J. Am. Chem. Soc. 1992, 114, 6568-6570. I511 C. Y. Cho, E. J. Moran, S. R. Cherry, J. C. Stephan, S. A. Fodor, C. L. Adams, A. Sundaram, J.

Jung, Eur. J. Biochem. 1976, 66, 11-23. [4] A. Kern, U. Kabatek, G. Jung, R. G. Werner, M. Poetsch, H. Dhner, Liebigs Ann. , 1985, 877-892. [S] K. Falk, 0. Rdtzschke, S. Stevanovic, G. Rammensee, Nature 1991, 351, 290-296. [a] 0. Rdtzschke, K. Falk, S. Stevanovic, B. Grahovac, M. J. Soloski, G. Jung, H A . Ram- mensee, Nature 1993, 361, 642-644. (71 G. Malcherek, V. Gnau, S. Rammensee, G. Jung, A. Melms, J. Immunol. 1994, 153, 1141- 1149. 16 I Natural Peptide Libraries of Microbial and Mammalian Origin [8] H.

V) Influencing Thermodynamic and Kinetic Stability of Polymer-bound Reagents: For example, by utilization of the template effect in asymmetric synthesis. (vi) Possibility of Automation: An automated synthesis is a precondition for the multiple and parallel synthesis of individual products and compound libraries applying combinatorial chemistry. 2 Supports and Anchors For the success of organic synthesis on solid supports, the correct choice of supports as well as their bound anchors (Fig. 2-1) is of utmost importance.

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