Coagulation. Current Research and Clinical Applications by Gottfried Schmer

By Gottfried Schmer

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I n t e r n . Med. 125:1016, 1970. M e r s k e y , C , J o h n s o n , A . J . , K l e w e r , G . J . , and W o h l , H . : The d e f i b r i n a t i o n syndrome: C l i n i c a l f e a t u r e s and l a b o r a t o r y d i a g n o s i s . Brit. J . Haemat. 1 3 : 5 2 8 , 1967. R o s n e r , F . , and R u b e n b e r g , M . L . : Erythrocyte f r a g m e n t a t i o n i n consumption c o a g u l o p a t h y . New E n g . J . Med. _280:219, 1969. Coleman, R . W . : F r a g m e n t a t i o n of e r y t h r o c y t e s .

May be p r e s e n t f o r l o n g p e r i o d s of t i m e . Would you comment on t h e u s e of t h i s t e s t ? Dr. Wolf: I h a v e h e a r d of i t but I h a v e no p e r s o n a l experience. D r . R a t n o f f , do you h a v e any e x p e r i e n c e w i t h t h i s assay? 35 P A U L L. W O L F Dr. Ratnoff: I h a v e used i t . T h e o r e t i c a l l y i t seems t o w o r k , and i t seems to be a l o t more a c c u r a t e t h a n what we do t o g e t t h e same r e s u l t s . J a c k Thompson: You mentioned consumption and t h e problems r e l a t e d t o c o n s u m p t i o n , and t h e r e a r e now many c a s e s r e p o r t e d and w e ' v e seen some o u r s e l v e s , where t h e r e was a s much i n j u r y from t h r o m b o s i s i n DIC a s t h e r e was from consumption i n D I C , i .

For e x a m p l e , i f consumption c o a g u l o p a t h y due t o p r i m a r y a c t i v a t i o n of t h e c o a g u l a t i o n of t h e c o a g u l a t i o n s y s ­ tem i s i n c o r r e c t l y t r e a t e d w i t h e p s i l o n a m i n o c a p r o i c a c i d , i t w i l l i n h i b i t t h e l i f e - s a v i n g a c t i v i t y of t h e s e c o n d a r i l y a c t i v a t e d f i b r i n o l y t i c s y s t e m , w h i c h keeps t h e p a t i e n t a l i v e by t h e r e m o v a l of f i b r i n a s i t i s formed.

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