Burger's Medicinal Chemistry and Drug Discovery, by Donald J. Abraham

By Donald J. Abraham

This is often quantity five: Chemotherapeutic brokers, of Burger's Medicinal Chemistry and Drug Discovery, sixth variation. This new quantity comprises serious new chapters on Molecular Biology of melanoma, man made Anti-angiogenic brokers and Selective Toxicities.To buy the total 6 quantity set, please consult with ISBN 0-471-37032-0.For an entire checklist of articles and members in addition to unfastened pattern chapters from this new sixth variation please stopover at: www.mrw.interscience.wiley.com/bmcdd

Show description

Read or Download Burger's Medicinal Chemistry and Drug Discovery, Chemotherapeutic Agents (Volume 5) PDF

Similar pharmacy books

Combinatorial Peptide and Nonpeptide Libraries: A Handbook

Reference on compound libraries of peptides, for researchers in natural synthesis, biochemistry, biotechnology, pharmacology, drugs, and scientific chemistry. wide assurance of artificial methods and applied sciences, mass spectrometry, and screening assays. forty seven individuals, 21 U. S.

Development of biopharmaceutical parenteral dosage forms

This up to the moment reference delineates-in a scientific fashion-the acceptable, sequential steps for the formula of secure, potent, strong, and marketable liquid parenteral biopharmaceutical products-covering basics and crucial pathways for every section in addition to its function, functionality, and relation to different phases within the product improvement approach.

Dietary Supplements and Functional Foods

The learn of dietary vitamins has turn into more and more very important inside of orthodox institutions in the course of the global, and because the marketplace for those items keeps to develop, so does the necessity for finished scientifically sound information regarding those items, their houses and capability wellbeing and fitness results.

Steroid-Protein Interactions

This can be the tale of steroid-protein interactions as one investigator sees it. Following the final suggestion of this monograph sequence, it emphasizes the implications and interpretations received within the author's laboratory, and is for this reason a subjective account. spotting, how­ ever, that the dialogue of the topic will be incomplete if the cloth have been restricted to 1 scientist's paintings, the basic in achieving­ ments of different investigators were integrated.

Extra resources for Burger's Medicinal Chemistry and Drug Discovery, Chemotherapeutic Agents (Volume 5)

Example text

Ras binds both guanosine 5'4riphosphate (GTP) and guanosine 5'-diphosphate (GDP) reversibly but is only in the activated state and capable of signaling when bound to GTP. The activated, GTP-bound form of ras signals a variety of mitogen-induced and stress-induced pathways, leading to transcription of genes necessary for cell growth and proliferation (74). Mitogens such as growth factors can activate ras through the epidermal growth factor receptor, and stress factors affecting ras include ultraviolet light, heat, and genotoxins.

By age 40, one or two of these polyps usually develops into a malignant carcinoma, and thus, many of these patients choose to have a colectomy to prevent carcinoma formation. Mutations in APC occur in the majority of sporadic colon cancers too. APC mutation is an earlv " event in colon carcinogenesis, and is therefore, considered to be the initiating event. Loss of this tumor suppressor gene results in constitutive activity of the oncogene, c-myc, through an intricate collection of protein-protein interactions.

It specifically dephosphorylates PtdIns-3,4,5-P3,antagonizing the function of PI-3K. PTEN, therefore, acts as a negative regulator of Akt activation. Because Akt can suppress apoptosis by the phosphorylation of the pro-apoptotic protein Bad, PTEN can induce apoptosis of mutated or stressed cells to prevent tumor formation. In addition to modulating apoptosis, PTEN plays a role in angiogenesis. PTEN suppresses the PI-3K-mediated induction of blood vessel growth factors like VEGF. EGF and ras act to induce genes regulated by the hypoxia-induced factor (HIF-I), which is blocked by PTEN activity.

Download PDF sample

Rated 4.56 of 5 – based on 48 votes