Biological Activity of Natural Products by Jaroslava Svarc-Gajic

By Jaroslava Svarc-Gajic

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Due to chemical diversity of potential marine threats, it is difficult to develop a standardized procedure for their detection. Bioaffinity tests are available only for well known and elucidated toxins. Alternative diagnostic tool may include administration of the extract of particular marine organism to experimental mice, however results of such tests are not readily available (Bhakuni and Rawat, 2005). Tetrodotoxin is a strong neurotoxin produced by different organisms, one of which is a fugu fish.

Tehnološki fakultet, Novi Sad, 1983. Riguera R. Isolating bioactive compounds from marine organisms. J Mar Biotech 5, 1997, 187-193. Roh SS, Lee MH, Hwang YL, Song HH, Jin MH, Park SG, Lee CK, Kim CD, Yoon TJ, Lee JH. Stimulation of the extracellular matrix production in dermal fibroblasts by velvet antler extract. Ann Derm. 22(2), 2010,173179. Švarc-Gajić J. Naturally occurring food toxicants. In: Nutritional insights in food safety (Ed: Švarc-Gajić J. Nova Science Publishers, New York, 2011), 39-99.

Medicinal Use of Alkaloids 49 Overdose of egometrine produces prolonged vasospasm resulting in permanent damage to blood vessels and gangrene development, hallucinations and possible abortions, for what it is contraindicated in pregnancy, vascular diseases and psychosis. Prolonged use of ergometrine decreases oxygen delivery to tissues due to constricted blood vessels. LSD or lysergic acid diethylamide is semisynthetic derivative that was first synthetized in 1938 by Albert Hofmann and is known for its hallucinogenic properties.

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