Basic & Clinical Pharmacology (LANGE Basic Science) 10th by Bertram Katzung

By Bertram Katzung

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Figure 2–3. Changes in agonist concentration-effect curves produced by a competitive antagonist (Panel A ) or by an irreversible antagonist (Panel B ). In the presence of a competitive antagonist, higher concentrations of agonist are required to produce a given effect; thus the agonist concentration (C') required for a given effect in the presence of concentration [I] of an antagonist is shifted to the right, as shown. High agonist concentrations can overcome inhibition by a competitive antagonist.

In the cell body the growth factor signal is transduced to transcription factors regulating the expression of genes controlling cell survival. This process effectively transports a critical survival signal from its site of release to its site of signaling effect, and does so over a remarkably long distance—more than 1 meter in certain sensory neurons. A number of regulators of growth and differentiation, including TGF- , act on another class of transmembrane receptor enzymes that phosphorylate serine and threonine residues.

Note that an endogenous ligand (eg, norepinephrine, acetylcholine, serotonin, many others not listed in Table 2–1) may bind and stimulate receptors that couple to different subsets of G proteins. The apparent promiscuity of such a ligand allows it to elicit different G proteindependent responses in different cells. For instance, the body responds to danger by using catecholamines (norepinephrine and epinephrine) both to increase heart rate and to induce constriction of blood vessels in the skin, by acting on Gs -coupled -adrenoceptors and G q -coupled 1 -adrenoceptors, respectively.

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